What is mitral valve regurgitation?
The mitral valve lies on the left side of the heart between
the left upper chamber (atrium) and lower chamber
(ventricle). The valve has 2 flaps called leaflets that
normally close every time the ventricle squeezes to pump
blood out of the heart. When the mitral valve doesn't close
properly, some of the blood from the ventricle is forced
back up (regurgitated) into the left atrium instead of
flowing out to the rest of the body. The added workload on
the heart and the increased blood pressure in the lungs may
eventually cause problems.
How does it occur?
Rheumatic fever can damage valve leaflets and cause
scarring. The scars can deform the leaflets so that they
don't close properly. A condition called mitral valve
prolapse can also cause mitral regurgitation. In mitral
valve prolapse one or both of the leaflets bulge (prolapse)
into the upper left chamber (atrium) of the heart. A small
amount of mitral regurgitation (MR) is common with mitral
valve prolapse.
If one or more of the cordlike structures attaching the
leaflets to the heart muscle breaks, the valve may leak.
Heart attacks, diseases of the heart muscle, or other heart
valve abnormalities may cause the whole heart to enlarge.
The enlargement stretches the mitral valve ring and muscular
attachments, pulling the valve leaflets apart. When the
leaflets no longer meet, leaking of the mitral valve
(mitral regurgitation) results.
Over time, the added workload on the heart may cause heart
failure. Heart failure occurs when the heart can't pump
enough blood to keep the lungs or other body tissues from
filling with fluid.
Mitral regurgitation may cause both the left ventricle and
left atrium to get larger. If the left atrium becomes big
enough, an irregular heart rhythm called atrial fibrillation
may result.
What are the symptoms?
People with mild to moderate MR may have no symptoms. Over
time, the added workload on the heart may cause shortness of
breath with exercise or an abnormal rhythm. This abnormal
rhythm feels like your heart is pounding, racing, or
skipping in your chest.
If a valve leaflet cord breaks, the sudden MR may quickly
cause heart failure. The main symptoms of heart failure
are:
- tiredness
- shortness of breath or trouble breathing, at first
during exercise and later with any activity or even when
you are resting
- waking up at night with trouble breathing or having a
hard time lying flat in bed because of shortness of
breath
- swollen ankles and feet and weight gain due to too much fluid in the body
- loss of appetite.
How is it diagnosed?
Most MR causes a heart murmur that can be heard through a
stethoscope and easily recognized. Enlargement of the heart
may be discovered during a physical examination.
The echocardiogram uses ultrasound waves to make pictures of
the heart. The pictures show the size of the heart
chambers, the thickness of the heart muscle, and the
movement of the heart valves. Doppler echo is a special
kind of ultrasound that shows the backflow of blood through
a valve. The echocardiogram can measure the amount of MR.
How is it treated?
If you have MR with a normal-sized heart and no symptoms,
you need no treatment except for antibiotics before having
dental work or procedures that involve the rectum, bladder,
or vagina. The antibiotics prevent infections from
starting on the mitral valve. Moderate to severe MR
eventually results in heart enlargement and symptoms. Most
people with symptoms will need valve repair or replacement.
If you delay treatment for too long, your heart muscle may
already be seriously damaged.
Surgery is often needed. If the valve is not too badly
deformed, it may be possible for the surgeon to repair it
instead of replacing it. Surgeons repair the existing valve
by narrowing the valve ring and tailoring the valve
leaflets. A plastic support ring is stitched around the
valve to bring the leaflets closer together. An advantage
of this kind of surgery is that long-term use of
blood-thinning drugs is not needed.
Sometimes the mitral valve leaflets are damaged so badly
that they must be replaced. Artificial heart valves made of
human or pig tissue work well but may not last as long as
man-made valves. They don't require long-term blood
thinners after surgery. Artificial mechanical valves also
work very well. These valves last longer without wearing
out, but blood thinners must be taken for life.
Other than surgery, drugs that expand (dilate) blood vessels
and slightly lower blood pressure are the only medicines
known to be helpful in treating MR. They work best for
those who are very ill, because they help them feel better.
Though the drugs work well at first, they don't seem to be
the answer for the long term.
How can I take care of myself?
- Check with your health care provider if your symptoms
worsen.
- Tell your dentist and other health care providers that
you have mitral valve regurgitation so you can make sure
that you take antibiotics when you need them to prevent
infection of the valve.
- Talk to your provider before you use any other medicines,
including nonprescription medicines.
- If you smoke, stop.
- Get regular checkups
- Lose weight if you are overweight.
- Learn ways to reduce or manage stress.
- Avoid taking aspirin if you're taking an anticoagulant (blood-thinning drug).
- Limit the salt in your diet if recommended by your provider.
- Ask your provider about a potassium supplement if you're taking diuretics that could cause potassium loss.
- If you have high blood pressure, make sure you follow your
health care provider's treatment plan for it.
- If you have significant mitral regurgitation, you should probably avoid heavy exercise.
- Tell all other health care providers you see that you have mitral valve stenosis.


Disclaimer: This content is reviewed periodically and is subject to
change as new health information becomes available. The
information provided is intended to be informative and educational and is not a
replacement for professional medical evaluation, advice, diagnosis or
treatment by a healthcare professional.
HIA File CRD3638F.HTM Release 9.0/2006. Copyright © 2006 McKesson Corporation and/or one of its subdiaries. All Rights Reserved.
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