In the 1940's, a hormone, called DES, was used to prevent problems in early pregnancies. It was given to women who had miscarriages, bleeding, or medical problems like diabetes. It was mostly given in large numbers of pills taken for several weeks.

In 1953, a study was done that showed that DES did not help. This drug, however, was used in the U.S. until 1971. Problems caused by this drug were found 20 years after its first use. The problems were found in the children of the mothers who took DES. They include:
* a rare type of vaginal and cervical cancer in young women in their teens and twenties,
* changes in the shape of the cervix and uterus, which may cause increased miscarriages, tubal pregnancies, and premature labor,
* changes in the urinary tract, such as an absent kidney or a double system, and
* in the male children, some changes in their reproductive system.

The drug's long term effects are now being studied. As women who were exposed age, their risk for all cancers, especially breast cancer, is being watched. To date, no increased risk has been found.

If you were born between 1940 and 1971 and think your mother took DES, the first step you should take is to talk with your doctor or a women's health service. They will direct you to a special service, if you need more testing. A special exam called a colposcopy will be done to check your vagina and cervix. A Pap smear will be taken with extra attention focused on the vaginal area. Other tests of the uterus and kidney systems may also be done. Counseling for any future problems, such as what can occur during pregnancy, is provided. A national listing of DES daughters exists so that if a future health problem is found, help can be offered.

Most women who have this exam, and are found free of any cancer at that date, will have little concern for a future, severe problem. By following up with future exams, early care and treatment can be given.

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